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Dosage must be adjusted in severe renal insufficiencyhigh doses may cause CNS toxicityincluding seizuressuperinfections and promotion of nonsusceptible organisms may occur with prolonged use or repeated therapy.

Children weighing more than 45 kg or older than 12 years should be treated with the recommended adult doseSUPRAXcefiximechewable tablets must be chewed or crushed before swallowing.

Thereforethe tablet or capsule should not be substituted for the chewable tablets or suspension in the treatment of otitis mediasee CLINICAL PHARMACOLOGY

Strep throat symptoms in infants and children are different than in adultsStrep throat is contagious and is generally passed from person-to-personTreatment for strep throat symptoms include home remedies and OTC medicationhoweverthe only cure for strep throat are antibiotics.

Alternative treatment of uncomplicated urogenitalanorectalor pharyngeal gonorrhea if ceftriaxone unavailableno longer indicated as first-line treatmentper CDC guidelines.

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